Abstract: A chip platform for thermally controlled biochemistry is presented and comprises post-processed thermally-isolated heated reaction sites atop an ASIC using PID feedback temperature control. The 384 sites can be individually programmed over 25-125°C, with thermal crosstalk below the +/- 0.12°C precision. Double-strand DNA purification via selective melting is demonstrated, with 70% retention of perfectly matched sequences, while 55% of those with two mismatched base-pairs are removed.
Bio: Michael C. W. Coln (IEEE SLM ‘24) received the B.S. degree in engineering from the California Institute of Technology, Pasadena, CA, USA in 1976, and the M.S. and Ph.D. degrees in electrical engineering from the Massachusetts Institute of Technology, Cambridge, MA, USA, in 1979 and 1985, respectively.
He was with Hewlett-Packard Laboratories, Palo Alto, CA USA, from 1985 to 1988 as a Member of Technical Staff in the area of high-performance data converters. Since 1988, he has been with Analog Devices, Boston, MA, USA, and is currently a member of the Analog Garage. He has developed monolithic architectures for extended signal chains, such as precision data acquisition ASICs for computed tomography and digital X-ray medical imaging. He has explored approaches for high-resolution ADCs in nanometer technologies, including digital-intensive calibration, and is currently focused on developing chip architectures and circuits for use in nucleic acid sequencing and synthesis. He has authored or co-authored several technical papers in the area of integrated circuit design and currently holds 63 U.S. patents.
Dr. Coln was recognized as an Analog Devices Fellow in 2005. He was a co-recipient of the Lewis Winner award for outstanding conference paper at ISSCC 2005, and the Jan van Vessem Best European Paper Award at ISSCC 2013.
Bio: Michael C. W. Coln (IEEE SLM ‘24) received the B.S. degree in engineering from the California Institute of Technology, Pasadena, CA, USA in 1976, and the M.S. and Ph.D. degrees in electrical engineering from the Massachusetts Institute of Technology, Cambridge, MA, USA, in 1979 and 1985, respectively.
He was with Hewlett-Packard Laboratories, Palo Alto, CA USA, from 1985 to 1988 as a Member of Technical Staff in the area of high-performance data converters. Since 1988, he has been with Analog Devices, Boston, MA, USA, and is currently a member of the Analog Garage. He has developed monolithic architectures for extended signal chains, such as precision data acquisition ASICs for computed tomography and digital X-ray medical imaging. He has explored approaches for high-resolution ADCs in nanometer technologies, including digital-intensive calibration, and is currently focused on developing chip architectures and circuits for use in nucleic acid sequencing and synthesis. He has authored or co-authored several technical papers in the area of integrated circuit design and currently holds 63 U.S. patents.
Dr. Coln was recognized as an Analog Devices Fellow in 2005. He was a co-recipient of the Lewis Winner award for outstanding conference paper at ISSCC 2005, and the Jan van Vessem Best European Paper Award at ISSCC 2013.